PlateKi 4.07.048

PlateKi 4.07.048


Size:5.2 MB

Date Added:22 June, 2012

Author: BioKin, Ltd.

Category: Multimedia & Graphics  >  CAD



The PlateKi application can be used in leading pharmaceutical research laboratories to determine "tight-binding"or "classical" inhibition constants from raw plate-reader data. Associated IC50 values are also determined for compatibility with most corporate databases. Benefits: - High processing speed (approximately 100 milliseconds per inhibition constant, including progress curve analysis). - Outlier exclusion minimizes labor and removes subjective bias. - Can be used for secondary in-vitro screening of purified enzymes, or in cell-based assays. - Summary output file can be imported into Excel and/or corporate databases. FEATURES: · Automatic model selection in fitting the reaction progress curves (straight line, quadratic parabola, first or second degree exponential). · Automatic initial estimate of the inhibition constant . · Optional robust regression with automatic exclusion of outliers . · Determination of nonsymmetrical confidence intervals for model parameters according to the profile-t method (Bates & Watts, 1988). · Fitting of dose-response curves either to the Morrison equation for tight binding or to the four-parameter logistic equation.

Systems: Windows 7, WinXP, Windows Vista, Windows Vista x64, Windows 7 x64

Tags: inhibition constant   determine constant   model selection   curve   analysis   analyze  

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